Synthesis and antitumor activities of phenanthrene-based alkaloids.
نویسندگان
چکیده
A series of phenanthrene-based tylophorine derivatives (PBTs) were synthesized and their cytotoxic activities against the H460 human large-cell lung carcinoma cell line were evaluated. Among these compounds, N-(3-hydroxy-2,6,7-tri-methoxyphenanthr-9-ylmethyl)-L-prolinol (5a), and N-(3-hydroxy-2,6,7-trimethoxy-phenanthr-9-ylmethyl)-L-valinol (9) exhibited good activities, with IC(50) values of 11.6 and 6.1 microM, respectively.
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ورودعنوان ژورنال:
- Molecules
دوره 14 12 شماره
صفحات -
تاریخ انتشار 2009